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Effects of a Partial Deletion of the Y Chromosome Azoospermia Factor (gr/gr Deletion) on Intracytoplasmic Sperm Injection Outcomes in East Asian Patients
https://doi.org/10.14994/tohojmed.2022-023
https://doi.org/10.14994/tohojmed.2022-02366e10e32-92f9-4d24-bf1f-23e1ea7a28f7
| 名前 / ファイル | ライセンス | アクション |
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td03559461.pdf (238.8 KB)
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| Item type | *学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2023-06-09 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Effects of a Partial Deletion of the Y Chromosome Azoospermia Factor (gr/gr Deletion) on Intracytoplasmic Sperm Injection Outcomes in East Asian Patients(en) | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | azoospermia factor, intracytoplasmic sperm injection, gr/gr deletion, testicular sperm extraction | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| ID登録 | ||||||||||||||||||
| ID登録 | 10.14994/tohojmed.2022-023 | |||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||
| 著者 |
Tamaki, Yuko
× Tamaki, Yuko
× Katagiri, Yukiko
× Fukuda, Yusuke
× Kobayashi, Hideyuki
× Nagao, Koichi
× Nakata, Masahiko
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| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Original Article | |||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Introduction: The azoospermia factor (AZF), located on the long arm of the Y chromosome, is involved in spermatogenesis. The gr/gr deletion, a partial deletion in the AZFc region, shows a high frequency in Asian men with infertility. Generally, gr/gr deletions do not strongly influence fertility in Asians; however, whether they affect intracytoplasmic sperm injection outcomes remains unclear. This study aimed to examine the effects of AZF deletions, particularly the gr/gr deletion, on intracytoplasmic sperm injection outcomes in East Asian subjects. Methods: East Asian patients (204) with a normal male karyotype who underwent AZF testing between July 2014 and August 2018 were selected for this retrospective study (ethics committee approval number: A18024). Results: Of the 204 East Asian subjects, 83 exhibited AZF deletions, of which 65 exhibited the gr/gr deletion. Thirty-seven patients in the gr/gr deletion group (56.9%) and seventy-seven in the group without AZF deletion (65.3%) were subjected to testicular sperm extraction (TESE), including microdissection-TESE (MD-TESE). Sperm retrieval was performed for 18 patients (48.6%) in the gr/gr deletion group and 36 patients (46.8%) in the group without AZF deletion. The fertilization rate, as ascertained using the TESE-derived sperms, was 54.8% (85/155) for the gr/gr deletion group and 66.5% (326/490) for the group without AZF deletion (p < 0.01). Conclusions: The fertilization rate was significantly lower for the sperm samples from the gr/gr deletion group than the control group. AZF gr/gr deletion did not affect spermatogenesis, but it may affect the fertilizing capacity of testicular sperms in East Asians. | |||||||||||||||||
| 書誌情報 |
ja : Toho Journal of Medicine en : Toho Journal of Medicine 巻 9, 号 2, p. 42-50, 発行日 2023-06-01 |
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| 出版者 | ||||||||||||||||||
| 出版者 | The Medical Society of Toho University | |||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||
| 収録物識別子 | 21891990 | |||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
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| 内容記述 | TD03559461 | |||||||||||||||||
| 資源タイプ(ローカル) | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | TOHO University Scholarly Publication | |||||||||||||||||
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| 内容記述 | Tokyo | |||||||||||||||||
