{"created":"2024-10-08T11:58:02.873082+00:00","id":2003004,"links":{},"metadata":{"_buckets":{"deposit":"8eaaf818-f02b-4257-a3ee-b91e845a79f5"},"_deposit":{"created_by":82,"id":"2003004","owner":"82","owners":[82],"pid":{"revision_id":0,"type":"depid","value":"2003004"},"status":"published"},"_oai":{"id":"oai:toho.repo.nii.ac.jp:02003004","sets":["1726902243533:1727660393378:1727661012807"]},"author_link":[],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"50","bibliographicPageStart":"42","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Toho Journal of Medicine","bibliographic_titleLang":"ja"},{"bibliographic_title":"Toho Journal of Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Original Article","subitem_description_language":"en","subitem_description_type":"Other"},{"subitem_description":"Introduction: The azoospermia factor (AZF), located on the long arm of the Y chromosome, is involved in spermatogenesis. The gr/gr deletion, a partial deletion in the AZFc region, shows a high frequency in Asian men with infertility. Generally, gr/gr deletions do not strongly influence fertility in Asians; however, whether they affect intracytoplasmic sperm injection outcomes remains unclear. This study aimed to examine the effects of AZF deletions, particularly the gr/gr deletion, on intracytoplasmic sperm injection outcomes in East Asian subjects. Methods: East Asian patients (204) with a normal male karyotype who underwent AZF testing between July 2014 and August 2018 were selected for this retrospective study (ethics committee approval number: A18024). Results: Of the 204 East Asian subjects, 83 exhibited AZF deletions, of which 65 exhibited the gr/gr deletion. Thirty-seven patients in the gr/gr deletion group (56.9%) and seventy-seven in the group without AZF deletion (65.3%) were subjected to testicular sperm extraction (TESE), including microdissection-TESE (MD-TESE). Sperm retrieval was performed for 18 patients (48.6%) in the gr/gr deletion group and 36 patients (46.8%) in the group without AZF deletion. The fertilization rate, as ascertained using the TESE-derived sperms, was 54.8% (85/155) for the gr/gr deletion group and 66.5% (326/490) for the group without AZF deletion (p < 0.01). Conclusions: The fertilization rate was significantly lower for the sperm samples from the gr/gr deletion group than the control group. AZF gr/gr deletion did not affect spermatogenesis, but it may affect the fertilizing capacity of testicular sperms in East Asians.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14994/tohojmed.2022-023","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Medical Society of Toho University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21891990","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1726887171532":{"attribute_name":"レコードID","attribute_value_mlt":[{"subitem_description":"TD03559461","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_1726887212651":{"attribute_name":"資源タイプ(ローカル)","attribute_value_mlt":[{"subitem_description":"TOHO University Scholarly Publication","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1726887247123":{"attribute_name":"出版地","attribute_value_mlt":[{"subitem_description":"Tokyo","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Obstetrics and Gynecology, Toho University Omori Medical Center","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Tamaki, Yuko","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Obstetrics and Gynecology, Toho University Omori Medical Center","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Katagiri, Yukiko","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Obstetrics and Gynecology, Toho University Omori Medical Center","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Fukuda, Yusuke","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Urology, Toho University Omori Medical Center","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kobayashi, Hideyuki","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Urology, Toho University Omori Medical Center","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Nagao, Koichi","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"Department of Obstetrics and Gynecology, Toho University Omori Medical Center","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Nakata, Masahiko","creatorNameLang":"en"}],"creatorType":"Author"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","displaytype":"detail","filename":"td03559461.pdf","filesize":[{"value":"238.8 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://toho.repo.nii.ac.jp/record/2003004/files/td03559461.pdf"},"version_id":"32b9f9d8-9fd5-4bdb-aee8-79e99c050aed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"azoospermia factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intracytoplasmic sperm injection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gr/gr deletion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"testicular sperm extraction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of a Partial Deletion of the Y Chromosome Azoospermia Factor (gr/gr Deletion) on Intracytoplasmic Sperm Injection Outcomes in East Asian Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of a Partial Deletion of the Y Chromosome Azoospermia Factor (gr/gr Deletion) on Intracytoplasmic Sperm Injection Outcomes in East Asian Patients","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"82","path":["1727661012807"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-06-09"},"publish_date":"2023-06-09","publish_status":"0","recid":"2003004","relation_version_is_last":true,"title":["Effects of a Partial Deletion of the Y Chromosome Azoospermia Factor (gr/gr Deletion) on Intracytoplasmic Sperm Injection Outcomes in East Asian Patients"],"weko_creator_id":"82","weko_shared_id":-1},"updated":"2024-12-06T08:08:11.091412+00:00"}