| 著者 |
Yorichika, Kubota
| en |
Yorichika, Kubota
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Hideaki, Shimada
| en |
Hideaki, Shimada
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Shunsuke, Magoshi
| en |
Shunsuke, Magoshi
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Fumi, Saito
| en |
Fumi, Saito
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Tadatoshi, Osaku
| en |
Tadatoshi, Osaku
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Tetsuo Nemoto
| en |
Tetsuo Nemoto
Department of Surgical Pathology (Omori), School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Hideaki, Ogata
| en |
Hideaki, Ogata
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Hironori, Kaneko
| en |
Hironori, Kaneko
Division of General and Gastroenterological Surgery (Omori), Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
|
|
内容記述 |
Serum p53 antibody (s-p53-Ab) is the most recently developed biomarker for breast cancer. Only a few studies have evaluated perioperative s-p53-Ab titers in patients with breast cancer. S-p53-Ab titers were monitored for over 4 years, during the perioperative period and after surgery, in a 75-year-old woman with clinical stage IIA (T2N0M0) breast cancer. The results of screening tests were negative for cancer antigen 15-3, carcinoembryonic antigen (CEA), and National Cancer Center-Stomach-439; only s-p53-Ab level (10.1 U/ml) was positive preoperatively. S-p53-Ab titer remained positive (9.1 U/ml) after radical surgery. Pathologic analysis of surgically resected specimens showed a stage IIB tumor (pT2N1M0). Two years postoperatively, CEA level had increased to 5.9 ng/ml. At this time, liver metastases were detected by computed tomography. Neither chemotherapy nor hormone therapy were effective against this recurrence, and the patient died 3 years after surgery. Perioperative s-p53-Ab titer was a useful marker for long-term monitoring of residual cancer cells in a patient with stage IIA breast cancer. |
TohoJMed002001022.pdf (235.1 KB)
