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Clinical and Experimental Research of Inflammatory Skin Diseases
https://doi.org/10.14994/tohojmed.2024-002
https://doi.org/10.14994/tohojmed.2024-00255a90f10-6f3c-47da-a74a-04fc59ca19f2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
td01216502.pdf (93.4 KB)
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| Item type | *学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2024-06-18 | |||||||
| タイトル | ||||||||
| タイトル | Clinical and Experimental Research of Inflammatory Skin Diseases(en) | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | autoimmune disease, drug eruption, psoriasis, dermadrome, immunotherapy | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.14994/tohojmed.2024-002 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Higuchi, Tetsuya
× Higuchi, Tetsuya
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| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Review Article | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Skin is the largest organ of the whole body, and the main function of the skin is to protect it from the external environment, both physically and immunologically. As an immune system, immune-mediated responses in the skin lead to skin eruptions, including papules, vesicles, and erythema. There are various chronic immune-mediated skin disorders, such as atopic dermatitis and psoriasis. Recent progress in understanding the mechanisms underlying these diseases has led to new treatment options, such as biologics or small-molecule kinase inhibitors. In this review, our clinical and experimental results on inflammatory skin diseases are referred to. In patients with Sjögren's syndrome, anti-SS-A antibody-related annular erythema is developed mainly on the face, whereas superficial spongiotic annular erythema is exhibited on the extremities. CD40 ligand (CD40L) is ectopically expressed on B cells in patients with systemic lupus erythematosus (SLE) and lupus-prone mice. With the analysis of CD40L transgenic mice, it is suggested that excessive CD40L signaling leads to the development of SLE. CD40L detection with flow cytometry in T cells in drug eruption patients is expected to diagnose the causative drug. Psoriasis is associated with obesity via various adipokines. We found that leptin production is upregulated in subcutaneous adipose tissue in patients with obese psoriasis and associated with disease activity. In inflammatory bowel disease patients, various skin eruptions are found in the clinical course, and evaluation and treatment by a dermatologist are important. As an approach to treating inflammatory skin disease, we investigated dextran nanoparticles, including antigen and dendritic cell activators, to enhance the antigen-specific immune response in mice. | |||||||
| 書誌情報 |
ja : Toho Journal of Medicine en : Toho Journal of Medicine 巻 10, 号 2, p. 28-34, 発行日 2024-06-01 |
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| 出版者 | ||||||||
| 出版者 | The Medical Society of Toho University | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 21891990 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| レコードID | ||||||||
| 内容記述 | TD01216502 | |||||||
| 資源タイプ(ローカル) | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | TOHO University Scholarly Publication | |||||||
| 出版地 | ||||||||
| 内容記述 | Tokyo | |||||||
