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Postrecurrence Prognostic Impact of Squamous Cell Carcinoma Antigen and Serum p53 Antibody at the Time of Recurrence on the Patients with Esophageal Squamous Cell Carcinoma
https://doi.org/10.14994/tohojmed.2021-018
https://doi.org/10.14994/tohojmed.2021-018fb371489-f1cb-43f0-90d3-a63234dabd36
| 名前 / ファイル | ライセンス | アクション |
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td09563496.pdf (258.5 KB)
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| Item type | *学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2022-06-14 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Postrecurrence Prognostic Impact of Squamous Cell Carcinoma Antigen and Serum p53 Antibody at the Time of Recurrence on the Patients with Esophageal Squamous Cell Carcinoma(en) | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | serum SCC antigen, serum p53 antibodies, esophageal squamous cell carcinoma, recurrence, prognosis | |||||||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||||||
| ID登録 | ||||||||||||||||||||||
| ID登録 | 10.14994/tohojmed.2021-018 | |||||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||||
| 著者 |
Moriyama, Jin
× Moriyama, Jin
× Suzuki, Takashi
× Oshima, Yoko
× Nanami, Tatsuki
× Yajima, Satoshi
× Shiratori, Fumiaki
× Funahashi, Kimihiko
× Shimada, Hideaki
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| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | Original Article | |||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | Introduction: Only a few papers have evaluated the postrecurrence prognostic impact of serum squamous cell carcinoma antigen (SCC-Ag) and serum p53 antibody (s-p53-Abs) on esophageal squamous cell carcinoma (ESCC) recurrence. Methods: A total of 218 patients with ESCC who underwent subtotal esophagectomy between 2009 and 2020 were enrolled. Among them, 67 patients developed recurrence by the end of 2020. The postrecurrence prognostic impact of SCC-Ag and s-p53-Abs on recurrence was evaluated. Results: SCC-Ag, but not s-p53-Abs, positivity increased significantly at recurrence. After combining both tumor markers, 52 of the 67 patients (78%) showed positivity at recurrence. The positivity of s-p53-Abs was not associated with postrecurrence prognosis. SCC-Ag positivity was slightly associated with poor postrecurrence prognosis, although the difference was not significant. Among the subgroups according to the SCC-Ag and the s-p53-Abs status at recurrence, the double-positive group showed the worst prognosis after recurrence. Conclusions: A combination of serum SCC-Ag and s-p53-Abs showed a high positivity rate of 78% at recurrence, and concurrent use of both the tumor markers may guide postoperative follow-up. | |||||||||||||||||||||
| 書誌情報 |
ja : Toho Journal of Medicine en : Toho Journal of Medicine 巻 8, 号 2, p. 79-88, 発行日 2022-06-01 |
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| 出版者 | ||||||||||||||||||||||
| 出版者 | The Medical Society of Toho University(en) | |||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 21891990 | |||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||
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| 内容記述 | TD09563496 | |||||||||||||||||||||
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| 内容記述 | TOHO University Scholarly Publication | |||||||||||||||||||||
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| 内容記述 | Tokyo | |||||||||||||||||||||
