| Item type |
*学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-02-08 |
| タイトル |
|
|
タイトル |
Metabolic Tumor Volume and Total Lesion Glycolysis in PET/CT are Related with the Clinicopathological T Stage of Colorectal Cancer and Predict its Prognosis(en) |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
FDG-PET/CT, colorectal cancer, metabolic parameter |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.14994/tohojmed.2018-024 |
|
ID登録タイプ |
JaLC |
| 著者 |
Hidenori, Kido
| en |
Hidenori, Kido
Department of Radiology (Omori), School of Medicine, Faculty of Medicine, Toho University / Department of General Medicine and Emergency Care, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Sunao, Mizumura
| en |
Sunao, Mizumura
Department of Radiology (Omori), School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Kimihiko, Funahashi
| en |
Kimihiko, Funahashi
Department of Surgery, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Kazutoshi, Shibuya
| en |
Kazutoshi, Shibuya
Department of Pathology, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Yoshihisa, Urita
| en |
Yoshihisa, Urita
Department of General Medicine and Emergency Care, School of Medicine, Faculty of Medicine, Toho University
|
Search repository
Atsuro, Terahara
| en |
Atsuro, Terahara
Department of Radiology (Omori), School of Medicine, Faculty of Medicine, Toho University
|
Search repository
|
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
ORIGINAL ARTICLE |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Introduction: Positron emission tomography (PET)/computed tomography (CT) plays an important role in cancer diagnosis. Recently, novel metabolic parameters obtained on PET/CT, such as metabolic tumor volume (MV) and total lesion glycolysis (TLG), have been reported to be diagnostic and prognostic biomarkers of various cancers. We evaluated the potential of these glucose metabolic parameters for the prognostic diagnosis of colorectal cancer (CRC), comparing them with conventional parameters such as the maximum standardized uptake value (SUV max) and maximum average SUV within a 1-cm3 spherical volume (SUV peak). Methods: This study included 82 patients who underwent surgical resection of CRC without distal metastasis between April 2015 and December 2017. They underwent [18F]-fluorodeoxyglucose-PET/CT and measurement of MV, TLG, SUV max, SUV mean, and SUV peak. After classifying the patients into four groups by pathological T stage, the metabolic parameters of each group were compared between the left- and right-sided large intestine using nonparametric multiple comparison test, and their prognosis was analyzed using Cox proportional hazards regression analysis. Results: The TLG value had a significant relation with the pathological T stage of the left-sided large intestine. Multivariate analysis of the clinicopathologic parameters (TLG, location, histological type, and T stage), revealed only the TLG of the primary tumor as an independent prognostic factor for recurrence within a year after surgery without distant metastasis. Conclusions: Our study results may suggest that TLG in PET/CT reflects a pathological T stage and plays a role in the prognosis of patients with local CRC. |
| 書誌情報 |
ja : Toho Journal of Medicine
en : Toho Journal of Medicine
巻 4,
号 4,
p. 132-140,
発行日 2018-12-01
|
| 出版者 |
|
|
出版者 |
The Medical Society of Toho University |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
21891990 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| レコードID |
|
|
内容記述 |
TD35135999 |
| 資源タイプ(ローカル) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
TOHO University Scholarly Publication |
| 出版地 |
|
|
内容記述 |
Tokyo |
td35135999.pdf (110.2 KB)
