| 著者 |
Hiroko, Izumi-Nakaseko
| en |
Hiroko, Izumi-Nakaseko
Department of Pharmacology, Faculty of Medicine, Toho Universit
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Wei, Li
| en |
Wei, Li
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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Xin Cao
| en |
Xin Cao
Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University
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Yuji, Nakamura
| en |
Yuji, Nakamura
Department of Pharmacology, Faculty of Medicine, Toho Universit
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Kentaro, Ando
| en |
Kentaro, Ando
Department of Pharmacology, Faculty of Medicine, Toho Universit
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Koichiro, Tanaka
| en |
Koichiro, Tanaka
Division of Traditional Japanese Medicine, Department of General Medicine and Emergency Care, Faculty of Medicine, Toho University
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Azjargal, Enkhsaikhan
| en |
Azjargal, Enkhsaikhan
Department of Pharmacology, Toho University Graduate School of Medicine
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Choijamts, Gotov
| en |
Choijamts, Gotov
Central Research Laboratory, Mongolian Traditional Medical and Training Centre “Manba Datsan” Otoch Manramba University
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Batkhuyag, Purevjav
| en |
Batkhuyag, Purevjav
Department of Pharmacology, School of Pharmacy and Bio-Medicine, Mongolian National University of Medical Sciences
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Yeruult, Chultemsuren
| en |
Yeruult, Chultemsuren
Department of Pharmacology, School of Pharmacy and Bio-Medicine, Mongolian National University of Medical Sciences
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Khaliun, Nyambayar
| en |
Khaliun, Nyambayar
Department of Pharmacology, School of Pharmacy and Bio-Medicine, Mongolian National University of Medical Sciences
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Narantungalag, Dorjsuren
| en |
Narantungalag, Dorjsuren
Department of Pharmacology, School of Pharmacy and Bio-Medicine, Mongolian National University of Medical Sciences
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Mihoko, Hagiwara-Nagasawa
| en |
Mihoko, Hagiwara-Nagasawa
Department of Pharmacology, Faculty of Medicine, Toho University
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Atsuhiko, T. Naito
| en |
Atsuhiko, T. Naito
Department of Pharmacology, Faculty of Medicine, Toho University
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Kazuo, Koike
| en |
Kazuo, Koike
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University
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Atsushi, Sugiyama
| en |
Atsushi, Sugiyama
Department of Pharmacology, Faculty of Medicine, Toho University
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内容記述 |
Background: Adonis mongolica (Ranunculaceae) is one of the endemic plants in Mongolia and has been used as a medicinal herb in Mongolian traditional medicine to treat patients with congestive heart failure showing tachycardia and edema. Although the plant has been empirically used in the last three decades, the precise information regarding its cardiovascular profile is still limited. Methods: We assessed the cardiohemodynamic and electrophysiological profile of the water-soluble extract of A. mongolica using the guinea pig in vivo model (n = 4) and in vitro preparation (n = 5 - 17). In addition, the onset mechanism of the extract-induced effects on the heart rate and blood pressure in vivo (n = 4), and the atrial rate and contractile force in vitro (n = 4 - 5) were pharmacologically analyzed. Results: The extract exerted the positive chronotropic, negative dromotropic, and vasopressor effects in addition to the proarrhythmic action in vivo. Meanwhile, it modestly decreased the atrial rate and aortic tension but increased the atrial contractile force in vitro. The pretreatment of dl-propranolol and prazosin significantly suppressed the positive chronotropic and vasopressor actions induced by the extract in vivo, indicating that the extract increased the sympathetic tone. Also, liquid chromatography-mass spectrometry analysis showed that water-soluble extract of A. mongolica contained eight kinds of cardiac glycosides. Conclusions: These results indicate that cardiac glycosides in the water-soluble extract of A. mongolica may explain currently observed various cardiovascular effects. |
td71598298.pdf (913.7 KB)
