{"created":"2024-10-08T05:06:52.679368+00:00","id":2002046,"links":{},"metadata":{"_buckets":{"deposit":"8c4e08bd-77f9-4947-8c40-fad52a95e25c"},"_deposit":{"created_by":82,"id":"2002046","owner":"82","owners":[82],"pid":{"revision_id":0,"type":"depid","value":"2002046"},"status":"published"},"_oai":{"id":"oai:toho.repo.nii.ac.jp:02002046","sets":["1724837505016:1727658618677:1727659852210"]},"author_link":[],"item_10001_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"146th Regular Meeting of the Medical Society of Toho University Panel Discussion: Current perspectives in pulmonary arterial hypertension research New insights regarding the pathogenic mechanisms underlying pulmonary vascular remodeling from endothelin receptor signaling","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"199","bibliographicPageStart":"197","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"東邦医学会雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the Medical Society of Toho University","bibliographic_titleLang":"en"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"総説","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"要約: 肺血管リモデリングは,肺動脈内皮細胞・平滑筋細胞の異常増殖とアポトーシス耐性獲得によって惹起される器質的な肺血管病変であり,肺動脈性肺高血圧症(pulmonary arterial hypertension:PAH)の発症・進展に深く関与している.エンドセリン-1(endothelin-1:ET-1)は,血管内皮細胞で産生される血管収縮性・炎症性ペプチドであり,PAHの病態形成において,重要な役割を担っている.ET-1によるエンドセリンA型受容体刺激は,transient receptor potential canonical 6(TRPC6)チャネルの活性化に伴う持続的なCa2+流入やRhoキナーゼの活性化を介して,肺血管リモデリングを引き起こす.一方,ET-1によるエンドセリンB型受容体の活性化は,血管内皮細胞における内皮由来弛緩因子の遊離および血中ET-1のクリアランスを介して,肺血管リモデリングの抑制に寄与する.本稿では,エンドセリン受容体シグナルに焦点を当て,肺血管リモデリングの発症機序と治療戦略について概説する.","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14994/tohoigaku.62.197","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東邦大学医学会","subitem_publisher_language":"ja"},{"subitem_publisher":"トウホウダイガクイガクカイ","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"The Medical Society of Toho 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エンドセリン受容体シグナルからの視点"],"weko_creator_id":"82","weko_shared_id":-1},"updated":"2024-12-18T00:39:20.488210+00:00"}