{"created":"2024-10-07T09:43:56.619097+00:00","id":2001701,"links":{},"metadata":{"_buckets":{"deposit":"c02ab547-ba59-416a-b7a6-58dc3a55267c"},"_deposit":{"created_by":82,"id":"2001701","owner":"82","owners":[82],"pid":{"revision_id":0,"type":"depid","value":"2001701"},"status":"published"},"_oai":{"id":"oai:toho.repo.nii.ac.jp:02001701","sets":["1724837505016:1727658622773:1727660207049"]},"author_link":[],"item_10001_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Successful use of Shakuyaku-kanzo-to to treat intractable hiccups due to cerebral infarction of the brain stem: Report of 2 cases","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"137","bibliographicPageStart":"133","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"東邦医学会雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of the Medical Society of Toho University","bibliographic_titleLang":"en"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"症例","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"脳幹梗塞に起因した難治性吃逆に芍薬甘草湯が奏効した2 症例を経験した.2 症例とも延髄外側に脳梗塞があり,眩暈,嘔吐,病側の顔面感覚障害と反対側の頸部以下の温痛覚障害,病側の小脳失調等を認め,Wallenberg 症候群を呈していた.症例1 は55 歳,男性.右延髄の脳梗塞後に5 日間以上持続する難治性吃逆を認めた.息こらえや咽頭刺激,chlorpromazine の内服で治療を行ったが軽快しなかった.芍薬甘草湯7.5 g/日を投与したところ,速やかに吃逆は消失した.症例2 は47 歳,男性.左延髄の脳梗塞後に難治性吃逆を併発した.咽頭刺激やmetoclopramide・chlorpromazine 投与で一時的に消失するも,断続的な吃逆を認めた.芍薬甘草湯7.5 g/日を投与したところ,吃逆は改善し,さらにchlorpromazine を追加することで完全に消失した.芍薬甘草湯は,副作用が少なく即効性の期待できる中枢性吃逆の治療薬の1 つとして考慮されるべき漢方薬であると考えられた.We describe the successful use of Shakuyaku-kanzo-toto treat 2 patients with intractable hic-cups due to brain stem infarction. The patients had developed lateral medullary infarction and presented with dizziness, vomiting, facial paresthesia, and cerebellar deficits on the infarction side; disturbance of pain sensation and temperature sensation below the neck on the contralateral side; and Wallenberg syndrome.Patient 1 was a 55-year-old man who had a right lateral medullary infarction, followed by intractable hiccups,i.e., hiccups persisting 5 days or longer. No improvement was noted after treatment with breath holding,pharyngeal stimulation, or chlorpromazine. However, treatment with 7.5g/day Shakuyaku-kanzo-topromptly resolved his hiccups. Patient 2 was a 47-year-old man who had a left lateralmedullary infarction, followed by intractable hiccups. Treatment with chlorpromazine and metoclopramide, in combination with pharyngeal stimulation, resulted in temporary improvement, but recurrence occurred shortly thereafter, and intermit-tent hiccups continued. Treatment with 7.5 g/day Shakuyaku-kanzo-to improved his hiccups, which com-pletely resolved after additional treatment with chlorpromazine. Shakuyaku-kanzo-tois an herbal medicine with limited side effects and potentially immediate action and should be considered for treatment of central hiccups.","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.14994/tohoigaku.59.133","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東邦大学医学会","subitem_publisher_language":"ja"},{"subitem_publisher":"トウホウダイガクイガクカイ","subitem_publisher_language":"ja-Kana"},{"subitem_publisher":"The Medical Society of Toho University","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00408670","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1726887171532":{"attribute_name":"レコードID","attribute_value_mlt":[{"subitem_description":"TD00493288","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_1726887212651":{"attribute_name":"資源タイプ(ローカル)","attribute_value_mlt":[{"subitem_description":"TOHO University Scholarly Publication","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1726887247123":{"attribute_name":"出版地","attribute_value_mlt":[{"subitem_description":"東京","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"原田, 雅史","creatorNameLang":"ja"},{"creatorName":"ハラダ, マサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Masashi","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(佐倉)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"安藤, 俊平","creatorNameLang":"ja"},{"creatorName":"アンドウ, シュンペイ","creatorNameLang":"ja-Kana"},{"creatorName":"Ando, Shunpei","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"福島, 大輔","creatorNameLang":"ja"},{"creatorName":"フクシマ, ダイスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukushima, Daisuke","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"植草, 啓之","creatorNameLang":"ja"},{"creatorName":"ウエクサ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Uekusa, Hiroyuki","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"北島, 悟","creatorNameLang":"ja"},{"creatorName":"キタジマ, サトル","creatorNameLang":"ja-Kana"},{"creatorName":"Kitajima, Satoru","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"野本, 淳","creatorNameLang":"ja"},{"creatorName":"ノモト, ジュン","creatorNameLang":"ja-Kana"},{"creatorName":"Nomoto, Jun","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"近藤, 康介","creatorNameLang":"ja"},{"creatorName":"コンドウ, コウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Kosuke","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"原田, 直幸","creatorNameLang":"ja"},{"creatorName":"ハラダ, ナオユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Harada, Naoyuki","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(佐倉)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宮崎, 親男","creatorNameLang":"ja"},{"creatorName":"ミヤザキ, チカオ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyazaki, Chikao","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"根本, 匡章","creatorNameLang":"ja"},{"creatorName":"ネモト, マサアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nemoto, Masaaki","creatorNameLang":"en"}],"creatorType":"Author"},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"東邦大学医学部脳神経外科学講座(大森)","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"周郷, 延雄","creatorNameLang":"ja"},{"creatorName":"スゴウ, ノブオ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugo, Nobuo","creatorNameLang":"en"}],"creatorType":"Author"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","displaytype":"detail","filename":"TOIZAG059003133.pdf","filesize":[{"value":"397.3 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://toho.repo.nii.ac.jp/record/2001701/files/TOIZAG059003133.pdf"},"version_id":"9748eea4-9d8b-4f44-b749-bf74f4d45203"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"芍薬甘草湯吃逆脳梗塞Wallenberg 症候群Shakuyaku-kanzo-tohiccupscerebral infarctionWallenberg syndrome","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"芍薬甘草湯","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"吃逆","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"脳梗塞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Wallenberg 症候群","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Shakuyaku-kanzo-to","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hiccups","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebral infarction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wallenberg syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脳幹梗塞に起因した難治性吃逆に芍薬甘草湯が奏功した2症例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳幹梗塞に起因した難治性吃逆に芍薬甘草湯が奏功した2症例","subitem_title_language":"ja"},{"subitem_title":"ノウカン コウソク ニ キイン シタ ナンチセイ キツギャク ニ シャクヤクカンゾウトウ ガ ソウコウ シタ 2 ショウレイ","subitem_title_language":"ja-Kana"},{"subitem_title":"NOKAN KOSOKU NI KIIN SHITA NANCHISEI KITSUGYAKU NI SHAKUYAKU-KANZO-TO GA SOKO SHITA 2 SHOREI","subitem_title_language":"ja-Latn"}]},"item_type_id":"10001","owner":"82","path":["1727660207049"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-07-22"},"publish_date":"2013-07-22","publish_status":"0","recid":"2001701","relation_version_is_last":true,"title":["脳幹梗塞に起因した難治性吃逆に芍薬甘草湯が奏功した2症例"],"weko_creator_id":"82","weko_shared_id":-1},"updated":"2024-12-06T08:06:45.140551+00:00"}